Meyers will usually set and ripen the most fruit in winter. So wait until most of the lemons have ripened before you prune your Meyer Lemon Tree. Then when you are ready to prune your tree, pick all (or most) the remaining ripe fruit off. Then prune any dead, damaged or diseased stems right to the base. Then start the longer task of pruning back the long wispy stems. Weak stems do not hold fruit well. Cut any that are smaller than a pencil. One that is done, cut any remaining smaller/medium size stems that are intercrossing the plant. You want to open the plant up to improve airflow, reduce disease, and make it easier to pick future setting fruit.   See Full Article

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